Drug Information Summary: Lucius Cabergoline Tablets

Disclaimer: This is a synthesized summary based on the known pharmacological profile of Cabergoline. This is not the official manufacturer's leaflet and does not replace professional medical advice.Cabergoline is a prescription drug with serious risks and must only be taken under the strict supervision of a physician.

1. Brand and Generic Name

• Generic Name: Cabergoline

• Brand/Manufacturer: Lucius Pharmaceuticals (Laos)

2. What is Cabergoline and what is it used for?

• Cabergoline is a long-acting dopamine receptor agonist.

• Primary Uses:

  • Hyperprolactinemia: Treatment of disorders associated with high levels of the hormone prolactin. This includes symptoms like galactorrhea (inappropriate milk production), amenorrhea (absence of menstruation), and infertility.

  • Parkinson's Disease: Management of signs and symptoms of Parkinson's disease, often as an adjunct to levodopa therapy.

3. Before you take Lucius Cabergoline
Do NOT take if you:

• Are allergic to cabergoline, any other ergot derivatives, or any of its ingredients.

• Have uncontrolled high blood pressure.

• Have a history of heart valve disease, fibrosis (scarring) of the heart or lungs, or pericarditis.

Warnings and Precautions:
Talk to your doctor about:

• Cardiac Valvopathy: Long-term, high-dose use (as in Parkinson's disease) has been associated with an increased risk of fibrotic changes and valve regurgitation in the heart. This risk is considered lower at the doses used for hyperprolactinemia. Your doctor may recommend cardiac monitoring (e.g., echocardiogram) before and during long-term treatment.

• Pleural and Pericardial Fibrosis: Rare cases of fibrosis around the lungs or heart have been reported.

• Drowsiness and Sudden Sleep Onset: Cabergoline may cause significant drowsiness or result in suddenly falling asleep during activities of daily living (e.g., driving, operating machinery). Exercise extreme caution until you know how the drug affects you.

• Low Blood Pressure (Hypotension): Can cause dizziness, lightheadedness, and fainting, especially when standing up quickly.

• Impulse Control Disorders: May cause uncontrollable urges to gamble, spend money, binge eat, or increased libido. Report any such behaviors to your doctor.

• Pregnancy and Breastfeeding: Used to treat infertility. Once pregnancy is confirmed, treatment is usually stopped. Discuss the risks and benefits with your doctor.

4. How to take Lucius Cabergoline

• Dosage: The dosage is highly individualized and must be determined by your doctor.

  • For Hyperprolactinemia: The typical starting dose is 0.25 mg to 0.5 mg twice per week. Your doctor will adjust the dose based on your prolactin levels.

  • For Parkinson's Disease: The dose is typically higher and administered daily.

• Administration: Take orally, with or without food.

• Missed Dose: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the regular time. Do not take a double dose.

5. Possible Side Effects
Common side effects may include:

• Nausea

• Vomiting

• Stomach pain

• Headache

• Dizziness

• Drowsiness or sudden sleep attacks

• Fatigue

• Constipation

• Low blood pressure (causing lightheadedness)

• Serious Side Effects (Contact your doctor immediately):

  • Shortness of breath, chest pain, cough (signs of lung or heart fibrosis).

  • Swelling in the legs or ankles.

  • Unusual urges (gambling, spending, eating).

  • Signs of heart valve problems (e.g., difficulty breathing, fatigue).

6. Drug Interactions
Inform your doctor about all medicines you are taking, especially:

• Other drugs that lower blood pressure (may increase dizziness).

• Antipsychotics or other drugs that antagonize dopamine (may reduce the effectiveness of cabergoline).

• Macrolide antibiotics (e.g., erythromycin) may increase cabergoline levels.

7. Storage

• Store below 30°C (86°F).

• Keep in the original container, tightly closed.

• Protect from light and moisture.

• Keep out of reach of children and pets.

8. Packaging

• Typically supplied in blister strips or a bottle.

Final Crucial Advice:
Cabergoline is an effective medication for specific hormonal and neurological conditions. Its use requires careful dose titration and monitoring for potential serious side effects, particularly related to the heart and impulse control. Do not drive or operate machinery until you are sure the medication does not make you drowsy. Always follow your doctor's specific instructions.

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